Áõ·Ê   Çлý¹ßÇ¥   °øÇØ   ¸é¿ªÄ¡·á   ÇÑÀÇÇп¡ ´ëÇÑ ³ªÀÇ ÀÌÇØ 
 
[¸ÞÀϸµ½Åû/Å»Åð]
  °íÁ¤°Ë»ö :  ¾Ë·¹¸£±â°³·Ð  /  ¾Ë·¹¸£°Õ  /  ±â°üÁöõ½Ä  /  ¾ÆÅäÇÇÇǺο°  /  À½½Ä¾Ë·¹¸£±â  /  µÎµå·¯±â  /  ¾Ë·¹¸£±âºñ¿° [ÃÖ½ÅÀÚ·á]
ÇöÀçÀ§Ä¡ : ¾Ë·¹¸£±â/È£Èí±â
 
 Ãâ·Â    ¸ÞÀÏ    ¸®½ºÆ®    Ãßõ
2¼¼ ¹Ì¸¸ÀÇ ¾ÆÅäÇÇÇǺο° ȯÀÚ¿¡¼­ ¿¤¸®µ¨ »ç¿ë

ÀÔ·ÂÀÏ:2008-04-20 / Á¶È¸¼ö:6108 / Ãßõ¼ö:269 / ÀÛ¼ºÀÚ:ÇѸ¸¿ë

2¼¼ ¹Ì¸¸ÀÇ ¾ÆÅäÇÇÇǺο° ȯÀÚ¿¡¼­ ¿¤¸®µ¨(1% Pimecrolimus)¿Í ÇÁ·ÎÅäÇÈ(0.03%, 0.1% Tacrolimus)À» »ç¿ëÇØµµ µÇ´Â°¡ÇÏ´Â ³íÁ¦´Â ³» ȨÆäÀÌÁöÀÇ ¿ª»çÀ̱⵵ ÇÏ´Ù.(ÇÁ·ÎÅäÇȰú ¿¤¸®µ¨¿¡ °üÇÑ ³ªÀǠȨÆäÀÌÁö Àǰß)

3³â Àü¿¡ ¹Ì±¹ ½Ä¾àû°ú ±¹³» ½Ä¾àû¿¡¼­ 2¼¼ ¹Ì¸¸ÀÇ ÇÁ·ÎÅäÇȰú ¿¤¸®µ¨À» 2¼¼ ¹Ì¸¸¿¡ »ç¿ë ±Ý±âÇÑ´Ù´Â ³»¿ëÀÇ °íÁö°¡ ÀÖÀº ÈÄ¿¡µµ(¾Ë·¹¸£±â ¾à¹°¿¡¼­ 'ºí·¢¹Ú½º' °æ°í¹®,  J Allergy Clin Immunol. 2006 Jan;117(1):40-4.) ³ª´Â ¿©ÀüÈ÷ Àüº¸´Ù´Â ¸¹Áö ¾ÊÁö¸¸ 6°³¿ù ÀÌ»ó µÇ°í 3°³¿ù ½ºÅ×·ÎÀ̵带 ²÷Áö ¸øÇÏ´Â ¾ÆÀ̸¦ ´ë»óÀ¸·Î ÇÁ·ÎÅäÇȰú ¿¤¸®µ¨À» ¾²°í ÀÖ¾ú´Ù. ±×·¯´ø Áß ÇÑ´Þ Àü¿¡ º´¿øÃø¿¡¼­´Â »è°¨ÀÌ ¸¹°í, »è°¨ÀÌ ¾ÈµÇ¾îµµ ±Ý±â¾àǰÀÌ °è¼Ó ó¹æµÇ´Â °ÍÀÌ ½Ä¾àû º¸°í°¡ °è¼ÓµÇ¸é¼­ »çȸ À̽´È­µÇ°í, ÀÌ·ÎÀÎÇØ ½Ä¾àû¿¡¼­ °­·ÂÇÑ °ø¹®À» º¸³»°í, º´¿øÀÇ ÀÔÀåÀÌ ³­Ã³Çϴٸ鼭 ¾Æ¿¹ ó¹æ ÀÚü¸¦ ¸øÇϵµ·Ï Àü»êÀ» ¸·¾Æ ¹ö·È´Ù.

»çȸ À̽´¿Í ±Ù¿ø ÀÚ·á "¿¬·É±Ý±â ¾àǰ 68,673°Ç ó¹æ" Ãâó : À庹½ÉÀÇ¿ø ¹Ì´Ï ȨÆäÀÌÁö

      ºÎÀÛ¿ëÀ¸·Î ÀÎÇØ °°ÀÌ Ã³¹æÇϰųª À¯¾Æ³ª ¾î¸°À̰¡ º¹¿ëÇØ¼­´Â µÇÁö ¾Ê´Â ¾àÀÌ Áö³­ 2004³â 8¿ù ÀÌÈÄ ±Ý³â 4¿ù±îÁö ÃÑ 6¸¸5,238¸í¿¡°Ô 6¸¸8,673°Ç ó¹æµÆ´ø °ÍÀ¸·Î µå·¯³µ´Ù.

      ÀÌ °°Àº »ç½ÇÀº °Ç°­º¸Çè½É»çÆò°¡¿ø(¿øÀå ±è⿱)ÀÌ ±¹È¸ º¸°Çº¹ÁöÀ§¿øÈ¸ ¼Ò¼Ó ´ëÅëÇÕ¹ÎÁֽŴç À庹½É(íåÜØãý·ºñ·Ê´ëÇ¥) ÀÇ¿ø¿¡°Ô Á¦ÃâÇÑ ¡®º´¿ë·¿¬·É±Ý±â ¾àǰ »ç¿ë½ÇÅ ºÐ¼®º¸°í¼­¡¯¿¡ ÀÇÇØ ¹àÇôÁ³´Ù.

      µ¿ ÀÚ·á¿¡ µû¸£¸é, º´¿ë±Ý±âÀÇ °æ¿ì Áö³­ 2004³â 3,209¸í¿¡°Ô 3,252°Ç, 2005³â 17,055¸í¿¡°Ô 17,328°Ç, 2006³â 5,181¸í¿¡°Ô 5,231°Ç ±×¸®°í ±Ý³â 4¿ù±îÁö 3,580¸í¿¡°Ô 3,928°ÇÀÌ Ã³¹æµÆ´ø °ÍÀ¸·Î µå·¯³µ´Ù. ¿¬·É±Ý±âÀÇ °æ¿ìµµ Áö³­ 2004³â 1,243¸í¿¡°Ô 1,263°Ç, 2005³â 25,555¸í¿¡°Ô 27,748°Ç, 2006³â 5,822¸í¿¡°Ô 6,036°Ç ±×¸®°í ±Ý³â 4¿ù±îÁö 3,593¸í¿¡°Ô 3,887°ÇÀÌ Ã³¹æµÅ ºÎÀûÁ¤ÇÑ Ã³¹æÀÌ ÁÙÁö ¾Ê°í ÀÖ´Â ½ÇÁ¤ÀÌ´Ù.

ÀÌ ¹Ùº¸°°Àº ±¹È¸ÀÇ¿ø ¶§¹®¿¡ ³ª´Â ÇѽÉÇÑ Àǻ簡 µÈ °ÍÀÌ´Ù. ÇÑ °Ç ÇÏ°í ½ÍÀº ±¹È¸ÀÇ¿øÀÌ ±¸Ã¼ÀûÀÎ »ç·Êµµ Àß ¸ð¸£¸é¼­ °ø¹«¿øµéÀÌ Àß ÇÏ´Â ¹æ½ÄÀ» ±×´ë·Î µû¶ó ÇÑ °ÍÀÌ´Ù. ¹Ùº¸°°Àº °ø°³Áö¸¸ °ø¹«¿øµéÀº °ð¹Ù·Î ¿òÁ÷¿´´Ù. ´Ù¾çÇÑ ±ÔÄ¢°ú ¾Ð¹ÚÀ» º´¿ø¿¡ ÇÑ °ÍÀÌ´Ù. ±×µéÀÌ ¾²´Â ¹æ½ÄÀº °£´ÜÇÏ´Ù. ±ÔÁ¤À» µéÀÌ¹Ð°í ¹üÁË º´¿ø Ãë±ÞÇÏ°í ¾à°ªÀ» »è°¨Çϰí, º´¿ø Æò°¡¿¡ Á¡¼ö¸¦ ±ï¾Æ ¹ö¸®°Ù´Ù´Â °ÍÀÌ´Ù. ±× °­·ÂÇÑ ÈûÀÌ º´¿øÀ» °ÅÃļ­ ÀÌ Á¶±×¸¸ ¼Ò¾Æ°ú ¿Ü·¡¿¡ ±Ù¹«ÇÏ´Â ³ª°°Àº '¼­¹ÎÀÇ»ç'¿¡°Ô Á÷Á¢ÀûÀ¸·Î ÆÄ°íµé¾ú´Ù.

À̸®ÇÏ¿©, ¿­¹ÞÀº ³ª´Â º´¿ø Á¶Á÷°ú 2½Ã°£ Á¤µµ ½Î¿ì°í ³­ÈÄ ³»°¡ ½Î¿ï »ó´ë´Â ¹Ùº¸ ±¹È¸ÀÇ¿øÀ̶ó´Â »ý°¢¿¡ ½Î¿òÀ» Æ÷±âÇØ ¹ö·È´Ù. ¿Ö ÀÌ·± ÀÏ¿¡ ³ªÀÇ ±ÍÁßÇÑ ÀÚ»êÀÎ ½Ã°£À» ³¶ºñÇϰí ÀÖ°í ³ªÀÇ ½Å°æÁúÀ» ¹ß»êÇÏ¿© ǰÀ§¸¦ ¶³¾îÆ®¸®´Â °¡¿¡ ´ëÇÑ È¸ÀÇÀÌ´Ù. ±×·¸°Ô ÇØ¼­ ÇÑ´Þ ÀüºÎÅÍ ³ª ¶ÇÇÑ ¹«·ÂÇÏ°Ô 2¼¼ ¹Ì¸¸ÀÇ ¾ÆÅäÇÇÇǺο° ¼Ò¾Æ¿¡¼­ ¿¤¸®µ¨°ú ÇÁ·ÎÅäÇÈÀ» ¾²Áö ¸øÇÏ°Ô µÇ¾ú´Ù.

À̸¦ '±â³ä'Çϱâ À§ÇØ ÇÑ ³í¹®À» Á¤¸®ÇϰíÀÚ ÇÑ´Ù. ÇÑ 2³â Àü¿¡ ³ª¿Â °ÍÀÌ´Ù. (Pediatrics 2006;117:e118. Safety and toleraility of 1% pimecrolimus cream among infants : experience with 1133 patients treated for up to 2 years.)

¿¬±¸ÀÚ´Â 2¼¼ ¹Ì¸¸ÀÇ ¾ÆÅäÇÇÇǺο° ȯÀÚ¿¡¼­ ¿¤¸®µ¨À» ¾²´Â °ÍÀÌ À§ÇèÇÑÁö ¾Æ´ÑÁö¸¦ È®ÀÎÇϰíÀÚ ÇÏ´Â ¿¬±¸ÀÌ´Ù.

¿¬±¸´Â ÀÌÁ¦±îÁö 2¼¼¹Ì¸¸ÀÇ ¼Ò¾Æ¿¡¼­ ¿¤¸®µ¨ Å©¸²À» »ç¿ëÇÏ¿© ¾ÆÅäÇÇ ÇǺο°À» Ä¡·á¿¡ ¿¬±¸ÇÑ ³í¹®À» ºÐ¼®ÇÏ´Â ¹æ½ÄÀ» »ç¿ëÇÏ¿´´Ù. 2³â ÀüÀÇ ³í¹®ÀÌ´Ï ´ç½Ã ¾àÁ¦ »ç¿ë¿¡ Black Box¶ó´Â ¶óº§À» ´ÞÀº ÈÄ¿¡ ÀÌ¿¡´ëÇÑ ´ëÀÀÀ¸·Î ³ª¿Â °ÍÀÌ´Ù.

¿µ¹® ÃÊ·Ï

    ¿¬±¸¿¡ Âü¿©ÇÑ 2¼¼ ¹Ì¸¸ÀÇ ¼Ò¾Æ´Â 3°³¿ù¿¡¼­ 23°³¿ùÀÇ 1,133¸íÀ̾ú´Ù. 4°³ÀÇ ¿¬±¸´Â ¾à·ÂÇп¡ ´ëÇÑ °ÍÀ̰í 6°³´Â ÀÓ»ó ¿¬±¸¿¡ ´ëÇÑ °ÍÀÌ´Ù. 35¸íÀÇ ¼Ò¾Æ¿¡¼­ Ç÷Á߳󵵸¦ ÃøÁ¤ÇÏ¿´À¸¸ç 80% À̻󿡼­ 1 ng/mL ÀÌÇÏ ³óµµ¿´´Ù. ÀÌ´Â ¾ÆÅäÇÇÇǺο°ÀÇ ½ÉÇÑÁ¤µµ¿Í ºÐÆ÷ ¹üÀ§¿Í °ü°è°¡ ¾ø¾ú´Ù. 1³â ÀÌ»ó °£ÇæÀûÀ¸·Î Ä¡·áµÇ¾úÀ» ¶§ ¾à¹°³óµµ¿¡´Â º¯È­°¡ ¾ø¾ú´Ù. ÀÌ·¯ÇÑ °á°ú´Â  2¼¼ ¹Ì¸¸¿¡¼­µµ ´Ù¸¥ ¿¬·ÉÀÇ ¼Ò¾Æ¿Í ¸¶Âù°¡Áö·Î ÇǺηΠÈí¼öµÇ´Â ¾à¹°ÀÌ ´õ ³ôÁö ¾Ê´Ù´Â °ÍÀ» ¸»ÇÑ´Ù.

    Àӻ󿬱¸´Â 1,098¸íÀÇ ¼Ò¾Æ°¡ ½ÃÇàµÇ¾ú°í 4°³¿ù¿¡¼­ 2³â°£ Ä¡·á¸¦ ¹Þ¾Ò´Ù. À̵é 60%°¡ Áߵ ¶Ç´Â ÁßÁõ ¾ÆÅäÇÇÇǺο°À» °¡Áö°í ÀÖ¾ú´Ù. °¡Àå ÈçÇÏ°Ô º¸°íµÈ ¾à¹° ºÎÀÛ¿ëÀº °¨±â, ¹ß¿­, »ó±âµµ °¨¿°, ÁßÀÌ¿°°ú ±â°üÁö¿°ÀÌÁö¸¸ Çö󼼺¸ Åõ¿©µÈ ¿¬±¸µµ ºñ½ÁÇÑ ºÎÀÛ¿ë ºóµµ¸¦ º¸¿´´Ù. ¿¤¸®µ¨À» ¾´ ȯÀÚ¿¡¼­ ÇǺΰ¨¿°ÀÌ ´õ ³ôÁö ¾Ê¾Ò°í ÇǺγ» ¼¼±Õ, °õÆÎÀÌ, ±â»ýÃæ°ú ¹ÙÀÌ·¯½º ºÐÆ÷  ¶ÇÇÑ Çö󼼺¸ Åõ¾à±º°ú °°¾Ò´Ù.

    ¿¤¸®µ¨À» ¹Ù¸¥ ȯÀÚ¿¡¼­ Ç츣Æä½º¼º ½ÀÁø (Æ÷Áø»ó ½ÀÁø, Eczema herpeticum)Àº 1000 ¸í´ç 0.8 °ÇÀÌ ¹ß»ýÇÏ¿´°í Çö󼼺¸¸¦ ¾´ ±×·ì¿¡¼­´Â 1.7 °ÇÀÌ ¹ß»ýÇÏ¿´´Ù. ÀÛ¿­°¨°ú ¹ßÁøÀº ¿¤¸®µ¨ ¾´ ȯÀÚ¿¡¼­ 1000¸í´ç 2¸í, Çö󼼺¸¸¦ ¾´ ±×·ì¿¡¼­ 1.2 ¸íÀÌ ³ªÅ¸³µ´Ù. ¸é¿ª ¾ïÁ¦¸¦ º¸ÀÎ ¿¬±¸ ´ë»ó±ºÀº ¾ø¾ú°í Àü½Å °¨¿°À̳ª ÇǺΰ¨¿°ÀÇ Áõ¼¼°¡ Áõ°¡ÇÑ´Ù´Â Áõ°Å¸¦ ãÁö ¸øÇÏ¿´´Ù.

Áß¿äÇÑ º»¹® ³»¿ë ¿ä¾à

    - ±¹¼Ò ½ºÅ×·ÎÀ̵å´Â ÇǺθ¦ ÅëÇØ Èí¼öµÇ°í(Percutaneous absorption) Àü½Å ºÎÀÛ¿ëÀ» ÀÏÀ¸Å³ °¡´É¼ºÀÌ ÀÖ´Ù. (¾ÆÅäÇÇÇǺο°À¸·Î ¾²´Â ±¹¼Ò ½ºÅ×·ÎÀ̵åÁ¦ÀÇ ¿ª°¡) ÀÌ·¯ÇÑ °¡´É¼ºÀº 'steroid phobia' ÁõÈıºÀ» À¯¹ßÇÏ¿© ÀÇ»ç-ȯÀÚ¿ÍÀÇ °ü°è¸¦ ±úÆ®¸®°Ô µÇ¾ú´Ù.

    - ¿¤¸®µ¨/ÇÁ·ÎÅäÇÈÀº ºÐÀÚ·®ÀÌ Å©°í ÁöÁú ģȭ¼º(lipophilicity)·Î ÀÎÇØ¼­ ±¹¼Ò ½ºÅ×·ÎÀ̵庸´Ù Àü½Å Èí¼öÀ²ÀÌ ¸Å¿ì ³·´Ù.

    - ÀÌ·¯ÇÑ ¾àÁ¦¸¦ 2¼¼ ¹Ì¸¸ÀÇ ¾ÆÅäÇÇÇǺο° ȯÀÚ¿¡¼­ »ç¿ëÇϸé Áõ»ó¿ÏÈ­, ¾ÇÈ­ ¿¹¹æ, ¾ÆÅäÇÇÇǺο° ȯÀÚÀÇ »îÀÇ Áú Çâ»ó µîÀÇ È¿°ú°¡ ÀÖ´Ù.

    - ±×·¯³ª 2¼¼ ¹Ì¸¸ÀÇ ¼Ò¾Æ¿¡¼­´Â ¹Ù¸£´Â ¾àÁ¦µéÀÌ Çе¿±â ¼Ò¾Æ³ª ¼ºÀκ¸´Ù Àü½Å Èí¼öÀ²ÀÌ ³ô±â¿¡ À§Ç輺Àº ´õ Å©°í ÀÌ¿¡µû¶ó ¾ÈÁ¤¼º¿¡ ´ëÇÑ ÀÚ·á°¡ ÇÊ¿äÇÏ´Ù.

    - ¼ºÀο¡¼­ Àü½ÅÀ¸·Î Pimecrolimus¸¦ Åõ¾à¹ÞÀº ȯÀÚ¿¡¼­ 12ÁÖµ¿¾È Ç÷Áß ÃÖ´ë ³óµµ´Â 54 ng/mL¿´À¸³ª µ¶¼º ºÎÀÛ¿ë º¸°í´Â ¾ø¾ú´Ù.

    - ±¹¼Ò ¿¤¸®µ¨À» 󹿹ÞÀº ÇÑ ¿¬±¸¿¡¼­¾ÆÀ̵鿡¼­ Ç÷Áß ¾à¹°À» °ÅÀÇ Ã£À» ¼ö ¾ø¾ú°í ÀÌ´Â 2½Ã°£, 4½Ã°£, 6½Ã°£, 12½Ã°£ ÈÄ¿¡µµ ÃÖ´ë ³óµµ¸¦ È®ÀÎÇÒ ¼ö ¾ø¾ù´Ù. ÀÌ·¯ÇÑ ¾à¹° ³óµµ´Â 4ÀÏ ÈÄ 22ÀÏ ÈÄ¿¡µµ À¯ÁöµÇ¾ú´Ù.

    - 4°³ÀÇ ´Ù¸¥ ¾à·ÂÇÐ ¿¬±¸¿¡¼­ üǥ¸éÀûÀÇ 10-92%¸¦ ¹Ù¸¥ ÈÄ, ¾î¶² ¿¬±¸¿¡¼­´Â ÀϳâÀÌ»ó Ä¡·á ±â°£À» À¯ÁöÇÑ ÈÄ ¾à¹° ³óµµ´Â 0.5  - 2 ng/mL ÀÌÇϸ¦ À¯ÁöÇÏ¿´´Ù. ÀÌ·¯ÇÑ ¿¬±¸°á°ú ¿µÀ¯¾Æ¿¡¼­ 1% ¿¤¸®µ¨À» »ç¿ëÇÏ´Â °ÍÀº Àü½Å Èí¼ö°¡ ¸Å¿ì Àû°í ±¤¹üÀ§ÇÑ ºÎÀ§¿¡ »ç¿ë °¡´ÉÇÏ´Ù´Â °ÍÀ» ÀǹÌÇÑ´Ù.

    - ÀÓ»ó°á°ú¿¡ µû¸£¸é ¾à¹° »ç¿ë ÈÄ 1ÁÖÀÏ À̳»¿¡ Áõ»ó È£ÀüÀ» º¸¿´°í 3°³¿ù À̳»¿¡ ÃÖ´ë Áõ»ó È¿°ú°¡ ÀÖ¾ú´Ù. ÀÌ·¯ÇÑ È¿°ú´Â 3°³¿ù ÀÌÈķεµ À¯ÁöµÇ¾ú´Ù. Ä¡·á ÈÄ 3°³¿ù°ú 9°³¿ù »çÀÌ¿¡ ¾à¹° »ç¿ë ¾çÀÌ ¸¹ÀÌ °¨¼ÒÇÏ¿´°í ÀÌÈÄ·Î ¾à¹° »ç¿ë·®Àº ÀûÀºÃ¤·Î À¯ÁöµÇ¾ú´Ù. Ä¡·á¸¦ ¾ÈÇÑ ±â°£ÀÌ 9°³¿ù µ¿¾È 50% Á¤µµ °¨¼ÒÇÏ¿´´Ù.

    - ¾à¹°À» ²÷´Â ºñÀ²Àº 9-25% Á¤µµ µÇ¾ú°í Çö󼼺¸´Â 29-48% Á¤µµ¿´´Ù. ¾à¹°À» ²÷´Â Áß¿äÇÑ ÀÌÀ¯´Â ¿¤¸®µ¨ »ç¿ë ±º¿¡¼­ 5.3%´Â Ä¡·áÈ¿°ú°¡ ¾ø¾î¼­, 3.4% ÃßÀû ½ÇÆÐ, 2.6% µ¿ÀÇÇÏÁö ¾ÊÀ½À̾ú°í ºÎÀÛ¿ëÀÌ ÀÇ½ÉµÇ¾î ²÷´Â ºñÀ²Àº 1.8%¿´´Ù.À̿ʹ޸® Çö󼼺¸¿¡¼­ ¾à¹° ²÷´Â ÀÌÀ¯ÀÇ ´ëºÎºÎÀº 14-41%´Â Ä¡·á È¿°ú°¡ ¾ø¾ú±â ¶§¹®ÀÌ´Ù.

    - ¾à¹°»ç¿ë ÈÄ ¿¹¹æÁ¢Á¾ÈÄ ¸é¿ª¹ÝÀÀÀ» ÁÙÀ̰ųª ¹æÇØÇÏ´Â °ÍÀº È®ÀÎÇÒ ¼ö ¾ø¾ú´Ù. ¿¹¹æÁ¢Á¾ Åõ¾à Àü À̳ª ÈÄ¿¡ ¾à¹° Åõ¾àÇÏ´Â °ÍÀÌ Áß¿äÇÏÁö ¾Ê¾Ò´Ù. ±×·¯¹Ç·Î ¾à¹°ÀÌ Àü½Å¿¡ Èí¼öµÇ°í ¸é¿ª¹ÝÀÀ¿¡ ¿µÇâÀ» Áشٴ Áõ°Å´Â ºÎÁ·ÇÏ´Ù.

°á·ÐÀûÀ¸·Î

    Àå±â°£ »ç¿ëµÇ¾úÀ» ¶§ ÇǺξÏ, ¸é¿ª¾ïÁ¦¿¡ ÀÇÇÑ ¸²ÇÁÁ¾ ¹ß»ý °¡´É¼ºÀÌ ¸é¿ª ¾ïÁ¦ ÀÛ¿ë È¿°ú·Î ÀÎÇØ Á¦±âµÉ ¼ö ÀÖ´Ù. ÀÌ·¯ÇÑ °¡´É¼ºÀº µ¿¹° ½ÇÇè¿¡¼­ °í¿ë·®À¸·Î Åõ¾àÇÏ¿´À» ¶§ ³ªÅ¸³­ °ÍÀÌ¸ç ¼Ò¾Æ¿¡¼­ È®ÀÎµÈ ¾à¹° ³óµµ¿¡ ºñÇØ 31-343 ¹è ¾à¹° ³óµµ°¡ ³ôÀº »óÅÂÀÌ´Ù. ¶ÇÇÑ 2³â ÀÌ»ó »ç¿ëÇÔ¿¡µµ ¸é¿ª ¹ÝÀÀÀ» ¾ïÁ¦ÇÑ´Ù´Â º¸°í´Â ¾ø´Ù.

    2001³â °Ü¿ï¿¡ ½ÃÆÇµÈ ÀÌÈÄ¿¡ ¿¤¸®µ¨ÀÌ ¾Ï ¹ß»ýÀÌ ³ô´Ù´Â º¸°í´Â ¾ø´Ù. ÀÌ´Â ÇâÈÄ Áö¼ÓÀûÀ¸·Î °üÂû ¿¬±¸°¡ Á¾·áµÇ¸é °á·ÐÀ» ³»¸± ¼ö ÀÖÀ» °ÍÀÌ´Ù.

    Ä¡·á È¿°ú¿Í Àü½Å Èí¼ö°¡ ³·±â¿¡ ¿¤¸®µ¨Àº ¿µÀ¯¾Æ¿¡¼­ ±¹¼Ò ½ºÅ×·ÎÀÌµå ´ë¿ëÀ¸·Î »ç¿ëÇÒ ¼ö ÀÖÀ» °ÍÀÌ´Ù.

 
100ÀÚÆò ¾²±â  À̸§: ÀÔ·ÂÀÏ:2023-12-02 
 
ÀÛ¼ºÀÚ : Royal CBD
zflICV I think other site proprietors should take this website as an model, very clean and wonderful user genial style and design, as well as the content. You are an expert in this topic!
ÀÛ¼ºÀÚ : best pron
X72V6v Just discovered this blog through Yahoo, what a way to brighten up my day!
ÀÛ¼ºÀÚ : click site
aGhbLr There is certainly a great deal to learn about this subject. I really like all the points you made.
ÀÛ¼ºÀÚ : suba buba
Tk3j4L It as nearly impossible to find well-informed people in this particular subject, however, you sound like you know what you are talking about! Thanks|
ÀÛ¼ºÀÚ : cuck your mom
ZrIHsN I usually do not create a bunch of responses, however i did a few searching and wound up right here?? -
ÀÛ¼ºÀÚ : porn videos
45JsSo Perfectly pent articles, Really enjoyed studying.
ÀÛ¼ºÀÚ : porn videos
Say, you got a nice blog article.Thanks Again. Awesome.
ÀÛ¼ºÀÚ : photo editor
vxXycO Thank you for your article post.Thanks Again. Really Great.
ÀÛ¼ºÀÚ : cocoservice
Y0J3LP My brother recommended I might like this website. He was entirely right. This post truly made my day. You cann at imagine simply how much time I had spent for this information! Thanks!
ÀÛ¼ºÀÚ : znwrAmVlFYuel
oXJVMc
ÀÛ¼ºÀÚ : crork
qq9CQP Muchos Gracias for your article.Much thanks again. Really Cool.
ÀÛ¼ºÀÚ : crork fiverr
XRMOz4 Fantastic blog article. Awesome.
ÀÛ¼ºÀÚ : seo service crork
V0TBBw Inspiring story there. What happened after? Take care!
ÀÛ¼ºÀÚ : alex crork
Hcv5ki I'а†ve read several good stuff here. Definitely price bookmarking for revisiting. I surprise how so much effort you put to create this kind of great informative web site.
ÀÛ¼ºÀÚ : crorkzz
3RMFHA of time to get rid of plaque. Be sure to give your self sufficient just about every early early morning and
ÀÛ¼ºÀÚ : crorkservice on five
pi1COm whoah this weblog is great i really like reading your posts. Stay up the great work! You recognize, lots of persons are looking around for this info, you can help them greatly.
ÀÛ¼ºÀÚ : crork work
WExFHt Fantastic web site. A lot of useful information here. I'm sending it to a few pals ans additionally sharing in delicious. And naturally, thank you on your effort!
ÀÛ¼ºÀÚ : good backlinks
GOue3u Wow, incredible blog format! How lengthy have you been running a blog for? you make running a blog look easy. The overall look of your site is fantastic, let alone the content material!
ÀÛ¼ºÀÚ : link building
MtVk7D Really informative article post.Really thank you! Great.
 
 
°íÁ¤°Ë»ö :  ¾Ë·¹¸£±â°³·Ð  /  ¾Ë·¹¸£°Õ  /  ±â°üÁöõ½Ä  /  ¾ÆÅäÇÇÇǺο°  /  À½½Ä¾Ë·¹¸£±â  /  µÎµå·¯±â  /  ¾Ë·¹¸£±âºñ¿°  
Á¤º¸Á¦°ø¿øÄ¢¤ÓÁ¤º¸°øÀ¯¹æ¿î¿µ¿øÄ¢¤ÓÀúÀ۱ǰü·Ã¤Ó°³ÀÎÁ¤º¸º¸È£¿øÄ¢¤ÓÀ̸ÞÀϹ«´Ü¼öÁý°ÅºÎ¤Ó°íÁ¤ÇÊÁø±¸ÇÔ¤ÓºñÁ¯°ú »ç¸í
¸ðµç ±ÛÀº ÀúÀÛ±Ç ¹ýÀÇ º¸È£¸¦ ¹Þ´Â ¹Ù ¹«´Ü ÀüÀç. º¹»ç. ¹èÆ÷µîÀ» ±ÝÇÕ´Ï´Ù.